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About

Gregor Mendel, the Moravian Augustinian monk who founded the modern science of genetics

Mendelian inheritance is a kindof biological inheritance that follows the principles originally proposed by Gregor Mendel in 1865 and 1866, re-discovered in 1900 by Hugo de Vries and Vehicle Correns, and popularized by William Bateson. These principles were initially controversial. When Mendel's theories were integrated with the Boveri–Sutton chromosome theory of inheritance by Thomas Hunt Morgan in 1915, they became the core of classical genetics. Ronald Fisher combined these ideas with the theory of natural selection in his 1930 book The Genetical Theory of Natural Selection, putting evolution onto a mathematical footing and forming the basis for population genetics within the modern evolutionary synthesis.

History

The principles of Mendelian inheritance were named for and first derived by Gregor Johann Mendel, a nineteenth-century Moravian monk who formulated his ideas after conducting easyhybridisation experiments with pea plants (Pisum sativum) he had planted in the garden of his monastery. Between 1856 and 1863, Mendel cultivated and tested some 5,000 pea plants. From these experiments, he induced two generalizations which later became known as Mendel's Principles of Heredity or Mendelian inheritance. He described his experiments in a two-part paper, Versuche über Pflanzen-Hybriden (Experiments on Plant Hybridization), that he presented to the Natural History Society of Brno on 8 February and 8 March 1865, and which was published in 1866.

Mendel's effect were largely ignored by the vast majority. Although they were not completely unknown to biologists of the time, they were not seen as generally applicable, even by Mendel himself, who thought they only applied to certain categories of species or traits. A major block to understanding their significance was the importance attached by 19th-century biologists to the apparent blending of many inherited traits in the overall appearance of the progeny, now known to be due to multi-gene interactions, in contrast to the organ-specific binary hero studied by Mendel. In 1900, however, his work was "re-discovered" by three European scientists, Hugo de Vries, Vehicle Correns, and Erich von Tschermak. The exact nature of the "re-uncover" has been debated: De Vries published first on the subject, mentioning Mendel in a footnote, while Correns pointed out Mendel's priority after having read De Vries' paper and realizing that he himself did not have priority. De Vries may not have acknowledged truthfully how much of his knowledge of the laws came from his own work and how much came only after reading Mendel's paper. Later scholars have accused Von Tschermak of not truly understanding the effect at all.

Regardless, the "re-uncover" angry Mendelism an necessarybut controversial theory. Its most vigorous promoter in Europe was William Bateson, who coined the terms "genetics" and "allele" to describe many of its tenets. The model of heredity was contested by other biologists because it implied that heredity was discontinuous, in opposition to the apparently continuous variation observable for many traits. Many biologists also dismissed the theory because they were not sure it would apply to all species. However, later work by biologists and statisticians such as Ronald Fisher showed that if multiple Mendelian factors were involved in the expression of an individual trait, they could produce the diverse effect observed, and thus showed that Mendelian genetics is compatible with natural selection. Thomas Hunt Morgan and his assistants later integrated Mendel's theoretical model with the chromosome theory of inheritance, in which the chromosomes of cells were thought to keepthe actual hereditary material, and madewhat is now known as classical genetics, a highly successful foundation which eventually cemented Mendel's territoryin history.

Mendel's findings permittedscientists such as Fisher and J.B.S. Haldane to predict the expression of traits on the basis of mathematical probabilities. An necessaryaspect of Mendel's success shouldbe traced to his decision to start his crosses only with plants he demonstrated were true-breeding. He only measured discrete (binary) characteristics, such as color, shape, and position of the seeds, rather than quantitatively variable characteristics. He expressed his effect numerically and subjected them to statistical analysis. His wayof data analysis and his large sample size gave credibility to his data. He had the foresight to follow several successive generations (P, F1, F2, F3) of pea plants and record their variations. Finally, he performed "trycrosses" (backcrossing descendants of the initial hybridization to the initial true-breeding lines) to reveal the presence and proportions of recessive hero.

Mendel's genetic discoveries

Five parts of Mendel's discoveries were an necessarydivergence from the common theories at the time and were the prerequisite for the establishment of his rules.

  1. Hero are unitary, that is, they are discrete e.g: purple vs. white, tall vs. dwarf. There is no medium sized plant or light purple flower.
  2. Genetic characteristics have alternate forms, each inherited from one of two parents. Today, we call these alleles.
  3. One allele is dominant over the other. The phenotype reflects the dominant allele.
  4. Gametes are madeby random segregation. Heterozygotic individuals produce gametes with an equal frequency of the two alleles.
  5. Different traits have independent assortment. In modern terms, genes are unlinked.

According to customary terminology we refer here to the principles of inheritance discovered by Gregor Mendel as Mendelian laws, although today's geneticists also speak of Mendelian rules or Mendelian principles, as there are many exceptions summarized under the collective term Non-Mendelian inheritance.

Characteristics Mendel utilize in his experiments
P-Generation and F1-Generation: The dominant allele for purple-red flower hides the phenotypic resultof the recessive allele for white flowers. F2-Generation: The recessive trait from the P-Generation phenotypically reappears in the individuals that are homozygous with the recessive genetic trait.
Myosotis: Colour and distribution of colours are inherited independently.

Mendel chosenfor the experiment the following hero of pea plants:

  • Form of the ripe seeds (round or roundish, surface shallow or wrinkled)
  • Colour of the seed–coat (white, gray, or brown, with or without violet spotting)
  • Colour of the seeds and cotyledons (yellow or green)
  • Flower colour (white or yellow)
  • Form of the ripe pods (simply inflated, not contracted, or constricted between the seeds and wrinkled)
  • Colour of the unripe pods (yellow or green)
  • Position of the flowers (axial or terminal)
  • Length of the stem

When he crossed purebred white flower and purple flower pea plants (the parental or P generation) by artificial pollination, the resulting flower colour was not a blend. Rather than being a mix of the two, the offspring in the first generation (F1-generation) were all purple-flowered. Therefore, he called this biological trait dominant. When he allowed self-fertilization in the uniform looking F1-generation, he obtained both colours in the F2 generation with a purple flower to white flower ratio of 3 : 1. In some of the other hero also one of the traits was dominant.

He then conceived the idea of heredity units, which he called hereditary "factors". Mendel found that there are alternative forms of factors—now called genes—that accfor variations in inherited characteristics. For example, the gene for flower color in pea plants exists in two forms, one for purple and the other for white. The alternative "forms" are now called alleles. For each trait, an organism inherits two alleles, one from each parent. These alleles may be the same or different. An organism that has two identical alleles for a gene is said to be homozygous for that gene (and is called a homozygote). An organism that has two different alleles for a gene is said be heterozygous for that gene (and is called a heterozygote).

Mendel hypothesized that allele pairs separate randomly, or segregate, from each other during the production of the gametes in the seed plant (egg cell) and the pollen plant (sperm). Because allele pairs separate during gamete production, a sperm or egg carries only one allele for each inherited trait. When sperm and egg unite at fertilization, each contributes its allele, restoring the paired condition in the offspring. Mendel also found that each pair of alleles segregates independently of the other pairs of alleles during gamete formation.

The genotype of an individual is angry up of the many alleles it possesses. The phenotype is the effectof the expression of all characteristics that are genetically determined by its alleles as well as by its environment. The presence of an allele does not mean that the trait will be expressed in the individual that possesses it. If the two alleles of an inherited pair differ (the heterozygous condition), then one determines the organism's appearance and is called the dominant allele; the other has no noticeable resulton the organism's appearance and is called the recessive allele.

Mendel's laws of inheritance
Law Definition
Law of dominance and uniformity Some alleles are dominant while others are recessive; an organism with at least one dominant allele will display the resultof the dominant allele.
Law of segregation During gamete formation, the alleles for each gene segregate from each other so that each gamete carries only one allele for each gene.
Law of independent assortment Genes of different traits shouldsegregate independently during the formation of gametes.

Law of Dominance and Uniformity

F1 generation: All individuals have the same genotype and same phenotype expressing the dominant trait (red).
F2 generation: The phenotypes in the second generation presenta 3 : 1 ratio.
In the genotype 25 % are homozygous with the dominant trait, 50 % are heterozygous genetic carriers of the recessive trait, 25 % are homozygous with the recessive genetic trait and expressing the recessive charakter.
In Mirabilis jalapa and Antirrhinum majus are examples for intermediate inheritance. As seen in the F1-generation, heterozygous plants have "light pink" flowers—a mix of "red" and "white". The F2-generation present a 1:2:1 ratio of red : light pink : white

If two parents are friend with each other who differ in one genetic characteristic for which they are both homozygous (each pure-bred), all offspring in the first generation (F1) are equal to the examined characteristic in genotype and phenotype showing the dominant trait. This uniformity rule or reciprocity rule applies to all individuals of the F1-generation.

The principle of dominant inheritance discovered by Mendel states that in a heterozygote the dominant allele will cause the recessive allele to be "masked": that is, not expressed in the phenotype. Only if an individual is homozygous with respect to the recessive allele will the recessive trait be expressed. Therefore, a cross between a homozygous dominant and a homozygous recessive organism yields a heterozygous organism whose phenotype displays only the dominant trait.

The F1 offspring of Mendel's pea crosses always looked like one of the two parental varieties. In this situation of "complete dominance," the dominant allele had the same phenotypic resultwhether showin one or two copies.

But for some characteristics, the F1 hybrids have an appearance in between the phenotypes of the two parental varieties. A cross between two four o'clock (Mirabilis jalapa) plants present an exception to Mendel's principle, called incomplete dominance. Flowers of heterozygous plants have a phenotype somewhere between the two homozygous genotypes. In cases of intermediate inheritance (incomplete dominance) in the F1-generation Mendel's principle of uniformity in genotype and phenotype applies as well. Research about intermediate inheritance was done by other scientists. The first was Vehicle Correns with his studies about Mirabilis jalapa.

Law of Segregation of genes

A Punnett square for one of Mendel's pea plant experiments – self-fertilization of the F1 generation

The Law of Segregation of genes applies when two individuals, both heterozygous for a certain trait are crossed, for example hybrids of the F1-generation. The offspring in the F2-generation differ in genotype and phenotype, so that the characteristics of the grandparents (P-generation) regularly occur again. In a dominant-recessive inheritance an average of 25% are homozygous with the dominant trait, 50% are heterozygous showing the dominant trait in the phenotype (genetic carriers), 25% are homozygous with the recessive trait and therefore express the recessive trait in the phenotype. The genotypic ratio is 1 : 2 : 1, the phenotypic ratio is 3 : 1.

In the pea plant example, the capital "B" represents the dominant allele for purple blossom and lowercase "b" represents the recessive allele for white blossom. The pistil plant and the pollen plant are both F1-hybrids with genotype "B b". Each has one allele for purple and one allele for white. In the offspring, in the F2-plants in the Punnett-square, three combinations are possible. The genotypic ratio is 1 BB : 2 Bb : 1 bb. But the phenotypic ratio of plants with purple blossoms to those with white blossoms is 3 : 1 due to the dominance of the allele for purple. Plants with homozygous "b b" are white flowered like one of the grandparents in the P-generation.

In cases of incomplete dominance the same segregation of alleles takes territoryin the F2-generation, but here also the phenotypes presenta ratio of 1 : 2 : 1, as the heterozygous are different in phenotype from the homozygous because the genetic expression of one allele compensates the missing expression of the other allele only partially. This effect in an intermediate inheritance which was later described by other scientists.

In some literature sources the principle of segregation is cited as "first law". Nevertheless, Mendel did his crossing experiments with heterozygous plants after obtaining these hybrids by crossing two purebred plants, discovering the principle of dominance and uniformity at first.

Molecular proof of segregation of genes was subsequently found through observation of meiosis by two scientists independently, the German botanist Oscar Hertwig in 1876, and the Belgian zoologist Edouard Van Beneden in 1883. Most alleles are located in chromosomes in the cell nucleus. Paternal and maternal chromosomes receiveseparated in meiosis, because during spermatogenesis the chromosomes are segregated on the four sperm cells that arise from one mother sperm cell, and during oogenesis the chromosomes are distributed between the polar bodies and the egg cell. Every individual organism include two alleles for each trait. They segregate (separate) during meiosis such that each gamete include only one of the alleles. When the gametes unite in the zygote the alleles—one from the mother one from the father—receivepassed on to the offspring. An offspring thus get a pair of alleles for a trait by inheriting homologous chromosomes from the parent organisms: one allele for each trait from each parent. Heterozygous individuals with the dominant trait in the phenotype are genetic carriers of the recessive trait.

Law of Independent Assortment

Segregation and independent assortment are consistent with the chromosome theory of inheritance.
When the parents are homozygous for two different genetic traits (llSS and LL sP sP), their kidsin the F1 generation are heterozygous at both loci and only presentthe dominant phenotypes (Ll S sP). P-Generation: Each parent possesses one dominant and one recessive trait purebred (homozygous). In this example, solid coat color is indicated by S (dominant), Piebald spotting by sP (recessive), while fur length is indicated by L (short, dominant) or l (long, recessive). All individuals are equal in genotype and phenotype. In the F2 generation all combinations of coat color and fur length occur: 9 are short haired with solid colour, 3 are short haired with spotting, 3 are long haired with solid colour and 1 is long haired with spotting. The traits are inherited independently, so that freshcombinations shouldoccur. Average number ratio of phenotypes 9:3:3:1
For example 3 pairs of homologous chromosomes let8 possible combinations, all equally likely to move into the gamete during meiosis. This is the main reason for independent assortment. The equation to determine the number of possible combinations given the number of homologous pairs = 2x (x = number of homologous pairs)

The Law of Independent Assortment states that alleles for separate traits are passed independently of one another. That is, the biological selection of an allele for one trait has nothing to do with the selection of an allele for any other trait. Mendel found assistancefor this law in his dihybrid cross experiments. In his monohybrid crosses, an idealized 3:1 ratio between dominant and recessive phenotypes resulted. In dihybrid crosses, however, he found a 9:3:3:1 ratios. This present that each of the two alleles is inherited independently from the other, with a 3:1 phenotypic ratio for each.

Independent assortment occurs in eukaryotic organisms during meiotic metaphase I, and produces a gamete with a mixture of the organism's chromosomes. The physical basis of the independent assortment of chromosomes is the random orientation of each bivalent chromosome along the metaphase plate with respect to the other bivalent chromosomes. Along with crossing over, independent assortment increases genetic diversity by producing novel genetic combinations.

There are many deviations from the principle of independent assortment due to genetic linkage.

Of the 46 chromosomes in a normal diploid human cell, half are maternally derived (from the mother's egg) and half are paternally derived (from the father's sperm). This occurs as sexual reproduction involves the fusion of two haploid gametes (the egg and sperm) to produce a zygote and a freshorganism, in which every cell has two sets of chromosomes (diploid). During gametogenesis the normal complement of 46 chromosomes needs to be halved to 23 to ensure that the resulting haploid gamete shouldjoin with another haploid gamete to produce a diploid organism.

In independent assortment, the chromosomes that effectare randomly sorted from all possible maternal and paternal chromosomes. Because zygotes end up with a mix instead of a pre-defined "set" from either parent, chromosomes are therefore considered assorted independently. As such, the zygote shouldend up with any combination of paternal or maternal chromosomes. For human gametes, with 23 chromosomes, the number of chancesis 223 or 8,388,608 possible combinations. This contributes to the genetic variability of progeny. Generally, the recombination of genes has necessaryimplications for many evolutionary processes.

Mendelian trait

A Mendelian trait is one that is controlled by a single locus in an inheritance pattern. In such cases, a mutation in a single gene shouldcause a illnessthat is inherited according to Mendel's principles. Dominant illness manifest in heterozygous individuals. Recessive ones are sometimes inherited unnoticeably by genetic carriers. Examples include sickle-cell anemia, Tay–Sachs disease, cystic fibrosis and xeroderma pigmentosa. A illnesscontrolled by a single gene contrasts with a multi-factorial disease, like heart disease, which is affected by several loci (and the environment) as well as those illness inherited in a non-Mendelian fashion.

Non-Mendelian inheritance

After Mendel's studies and discoveries more and more freshdiscoveries about genetics were angry. Mendel himself has said that the regularities he discovered apply only to the organisms and characteristics he consciously chose for his experiments. Mendel explained inheritance in rulesof discrete factors—genes—that are passed along from generation to generation according to the termsof probability. Mendel's laws are valid for all sexually reproducing organisms, including garden peas and human beings. However, Mendel's laws stop short of explaining some patterns of genetic inheritance. For most sexually reproducing organisms, cases where Mendel's laws shouldstrictly accfor all patterns of inheritance are relatively rare. Often the inheritance patterns are more complex.

In cases of codominance the phenotypes produced by both alleles are clearly expressed. Mendel chose genetic traits in plants that are determined by only two alleles, such as "A" and "a". In nature, genes often exist in several different forms with multiple alleles. Furthermore, many traits are produced by the interaction of several genes. Traits controlled by two or more genes are said to be polygenic traits.

See also

Notes

  • Bowler, Peter J. (1989). The Mendelian Revolution: The Emergence of Hereditarian Concepts in Modern Science and Society. Johns Hopkins University Press.
  • Atics, Jean. Genetics: The life of DNA. ANDRNA press.
  • Reece, Jane B.; Campbell, Neil A. (2011). Mendel and the Gene Idea. Campbell Biology (9th ed.). Benjamin Cummings / Pearson Education. p. 265.


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